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Causes

The exact cause of ulcerative colitis is unknown, although it's thought to be the result of a problem with the immune system.

Autoimmune condition

The immune system is the body's defence against infection. Some experts believe ulcerative colitis is an autoimmune condition (when the immune system mistakenly attacks healthy tissue).

The immune system normally fights off infections by releasing white blood cells into the blood to destroy the cause of the infection.

This results in swelling and redness (inflammation) of body tissue in the infected area.

In ulcerative colitis, a theory is that the immune system mistakes "friendly bacteria" in the colon, which aid digestion, as a harmful infection, leading to the colon and rectum becoming inflamed.

Alternatively, some researchers believe a viral or bacterial infection triggers the immune system, but for some reason it does not "turn off" once the infection has passed and continues to cause inflammation.

It's also been suggested that no infection is involved and the immune system may just malfunction, or that there's an imbalance between good and bad bacteria within the bowel.

Genetics

It also seems inherited genes may be a factor in the development of ulcerative colitis.

You may be more likely to have ulcerative colitis if you have a close relative with the condition.

Researchers have identified several genes that seem to make people more likely to develop ulcerative colitis.

It's believed many of these genes play a role in the immune system.

Environmental factors

Where and how you live also seems to affect your chances of developing ulcerative colitis, which suggests environmental factors are important.

For example, the condition is more common in urban areas of northern parts of western Europe and America.

Various environmental factors that may be linked to ulcerative colitis have been studied, including air pollution, medicine and certain diets.

Although no factors have so far been identified, countries with improved sanitation seem to have a higher population of people with the condition.

This suggests that reduced exposure to bacteria may be an important factor.

Last Reviewed
08 November 2022
NHS websiteNHS website

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Established in 1983, Blackwells Chemist has been around for 43 years in the current hands of Piyush Amin, providing excellence care and personal professional advice. Over time, we have secured our reputation to thousands of patients as "their long term family pharmacist" due to our specialist advice, care and attention served and tailored to each and every patient and their needs.

As well as the standard pharmacy prescription services and healthcare retail products, we also offer a wide range of healthcare services including antigen and antibody testing, a travel and vaccination clinic, a seasonal flu & covid jab service, blood pressure monitoring, addiction clinics, health screening services, Pharmacy First and a range of over 12,000 product lines stocked in store.

We serve all of Beckenham, Bromley, Park Langley, Penge, Crystal Palace, West Wickham, Shirley, Eden Park, Elmers End, Shortlands and further afield. 

Ask your local GP about our sterling reputation, for both excellence in care as well as stocked products.
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